REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-FXN	Proteintech	Cat # 14147-1-AP; RRID: AB_2231876
Rabbit anti-GAPDH	Abcam	Cat #ab9485; RRID: AB_307275
Rabbit anti-PRDX3	Abclonal	Cat #A2398; RRID: AB_2863001
Rabbit anti-Nanog	Abcam	Cat #109250; RRID: AB_10863442
Rabbit anti-TFR1	Abclonal	Cat #A5865; RRID: AB_2766615
Mouse anti-P53	Abclonal	Cat #A10610; RRID: AB_2758147
Mouse anti-Tubulin	Proteintech	Cat #66031-1-Ig; RRID:AB_11042766
Goat anti-mouse IgG (H+L)	Thermo Fisher Scientific	Cat #31430; RRID:AB_228307
Goat anti-rabbit IgG (H+L)	Thermo Fisher Scientific	Cat #31460; RRID: AB_228341
Bacterial and virus strains
Lentivirus-expressing GV112 - shCtrl	This paper	N/A
Lentivirus-expressing GV112 - sh-FXN2	This paper	N/A
Biological samples
Formed tumors in BALB/c Nude mice	This paper	N/A
Ovarian cancer tissue	This paper	N/A
Paraffin-embedded ovarian cancer specimens	This paper	N/A
Chemicals, peptides, and recombinant proteins
TRIzol reagent	Thermo Fisher Scientific	Cat# 15596018
RIPA buffer	Thermo Fisher Scientific	Cat# 89900
Proteinase inhibitor cocktail	Thermo Fisher Scientific	Cat# 7843
Puromycin	Thermo Fisher Scientific	Cat# A1113803
Erastin	MCE	Cat# HY-15763
RSL3	MCE	Cat# HY-100218A
CM-H2DCFDA	Sigma-Aldrich	Cat #287810
CCK reagent	Dojindo	Cat #CK04
Critical commercial assays
PrimeScript™ RT reagent Kit with gDNA Eraser kit	Takara	Cat# RR047A
SYBR® Premix Ex Taq™ II (Tli RNaseH Plus)	Takara	Cat# RR820A
SuperSignal® West Pico Chemiluminescent Substrate	Thermo Fisher Scientific	Cat# 34578
Calcein-AM/PI kit	Yeasen	Cat# 40747ES76
Deposited data
Proteomics	This study	iPROX: IPX0007691000
Experimental models: Cell lines
Skov3	ATCC	Cat# HTB-77
Ovcar5	Lab stock	N/A
Experimental models: Organisms/strains
BALB/c Nude mice	Hangsi biological	N/A
Oligonucleotides
shRNA targeting sequence: shFXN2: GAACCTATGTGATCAACAA	This paper	N/A
SiRNA targeting sequences, see Table S3	This paper	N/A
Primers used for qRT-PCR, see Table S4	This paper	N/A
Primers used for plasmid construction, see Table S4	This paper	N/A
Recombinant DNA
LT-Flag vector	This paper	N/A
LT-Flag FXN	This paper	N/A
Software and algorithms
GraphPad Prism 8.0	GraphPad	https://www.graphpad.com/
FlowJo X software	Ashland	https://www.flowjo.com/
Image Lab 5.2	BIO-RAD	https://www.bio-rad.com/zh-cn/product/image-lab-software?ID=KRE6P5E8Z
ImageJ software	National Institutes of Health	https://ImageJ.en.softonic.com/mac
Other
Lipofectamine™ RNAiMAX	Thermo Fisher Scientific	Cat# 13778150
Opti-MEMTM I medium	Thermo Fisher Scientific	Cat# 31985088
DMEM/F12 medium	BI	Cat# 06-1170-87-1A
B27 additive	Life Technologies	Cat# 17504044
Insulin	Sigma-Aldrich	Cat# 91077C
Human EGF Recombinant Protein	Thermo Fisher Scientific	Cat# AF-100-15-1MG
Human FGF-basic (FGF-2/bFGF)	Thermo Fisher Scientific	Cat# AF-100-18B-1MG