REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
FITC anti-human CD14	Biolegend	Cat# 367116; RRID: AB_2571929
PE anti-human CX3CR1	Biolegend	Cat# 341604; RRID: AB_1595456
PE-Cy5 anti-human CD11b	Biolegend	Cat# 301308; RRID: AB_314160
PE-Cy7 anti-human HLA-DR	Biolegend	Cat# 307616; RRID: AB_493588
APC anti-human CD192 (CCR2)	Biolegend	Cat# 357208; RRID: AB_2562239
APC-Cy7 anti-human CD68	Biolegend	Cat# 333822; RRID: AB_2571965
PE anti-human P2RY12	Biolegend	Cat# 392104; RRID: AB_2716007
APC anti-human MERTK	Biolegend	Cat# 367612; RRID: AB_2687289
KO anti-human CD45	BeckmanCoulter Life Sciences	Cat# B36294
Biological samples
Peripheral blood from healthy donors	Catalan Blood and Tissue Bank	N/A
Chemicals, peptides, and recombinant proteins
RPMI Medium 1640+ GlutaMAXTM	Gibco, Thermo Fisher	Cat# 61870036
α-minimal essential medium (α-MEM)	Invitrogen	Cat# 32561-029
Penicillin – Streptomycin	Labclinics, S.A.	L0022-100
Human M-CSF	Peprotech	Cat# 300-25
Human GM-CSF	Peprotech	Cat# 300-03
Human beta-NGF	Peprotech	Cat# 450-01
Human MCP-1/MCAF (CCL2)	Peprotech	Cat# 300-04
Human IL-34	Peprotech	Cat# 200-34
Human TGF-beta 2 (Mammalian)	Peprotech	Cat# 100-35B
Cholesterol	Merck	Cat# C3045-5G
ATP (adenosine 5′-triphosphate disodium salt)	InvivoGen	Cat# tlrl-atpl
LPS (lipopolysaccharide)	Merk	Cat# C3045-5G
FBS (Fetal Bovine Serum)	ThemoFisher Scientific	Cat# 10270106
PBS	ThemoFisher Scientific	Cat# 20012019
Paraformaldehyde	Aname, SL	Cat# 15710-S
Versene	ThemoFisher Scientific	Cat# 15040033
Critical commercial assays
CD14+ MicroBeads	Miltenyi Biotec	Cat# 130-050-201
Maxwell RSC simplyRNA Cells Kit	Promega	Cat# AS1390
Transcriptor First Strand cDNA Synthesis Kit	Roche	Cat# 4897030001
LightCycler® 480 SYBR Green Mix	Roche	Cat# 4887352001
IL-1 beta Human ELISA Kit	Invitrogen	Cat# KHC0011
LIVE/DEADTM Fixable Violet	ThemoFisher Scientific	Cat# L34964
Deposited data
DNA methylation and gene expression	This paper	GSE235104
Oligonucleotides
qRT-PCR primers, see STAR method details	This paper	N/A
Software and algorithms
Primer3	Koressaar et al.73	https://primer3.ut.ee/
shinyÉpico	Morante-Palacios et al.74	https://github.com/omorante/shinyepico
Minfi	Aryee et al.75	https://bioconductor.org/packages/release/bioc/html/minfi.html
Limma	Ritchie et al.76	https://bioconductor.org/packages/release/bioc/html/limma.html
Sva	Leek et al.77	https://bioconductor.org/packages/release/bioc/html/sva.html
HISAT2	Kim et al.78	https://daehwankimlab.github.io/hisat2/
featureCounts	Liao et al.79	https://subread.sourceforge.net/featureCounts.html
DESeq2	Love et al.80	https://bioconductor.org/packages/release/bioc/html/DESeq2.html
Seurat	Hao et al. (2021 and 2023)81,82	https://satijalab.org/seurat/
DoubletFinder	McGinnis et al.83	https://github.com/chris-mcginnis-ucsf/DoubletFinder
Sccomp	Mangiola et al.84	https://github.com/MangiolaLaboratory/sccomp
Gplots	Warnes et al.85	https://cran.r-project.org/web/packages/gplots/index.html
ComplexHeatmap	Gu et al.86	https://bioconductor.org/packages/release/bioc/html/ComplexHeatmap.html
Gviz	Hahne et al.87	https://bioconductor.org/packages/release/bioc/html/Gviz.html
VennDiagram	Chen et al.88	https://cran.r-project.org/web/packages/VennDiagram/index.html
HOMER	Heinz et al.89	http://homer.ucsd.edu/homer/motif/
GREAT	McLean et al.90	http://great.stanford.edu/public/html
DoRothEA	Garcia-Alonso et al.91	https://saezlab.github.io/dorothea/articles/dorothea.html
clusterProfiler	Wu et al.92	https://guangchuangyu.github.io/software/clusterProfiler/
GeneOverlap	Shen et al.93	https://github.com/shenlab-sinai/GeneOverlap
Fgsea	Korotkevich et al.94	https://www.bioconductor.org/packages/release/bioc/html/fgsea.html