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. 2024 Aug 12;28(4):492. doi: 10.3892/ol.2024.14625

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Copyright: © 2024 Sun et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 6. — MTCH2 regulated claudin-3 expression levels through AIMP2. (A and B) Co-IP assay verified the binding between MTCH2 and AIMP2 in SK-OV-3 cells. (C and D) The efficiency of AIMP2 knockdown was validated using western blotting. (E) The expression levels of (F) MTCH2, (G) claudin-3 and (H) AIMP2 were detected by western blot following the transfection of NC-siRNA, AIMP2 siRNA, AIMP2 siRNA2, AIMP2 siRNA + MTCH2 siRNA and AIMP2 siRNA + MTCH2-OE. *P<0.05, **P<0.01 and ***P<0.001. IP, immunoprecipitation; MTCH2, mitochondrial carrier homology 2; AIMP2, aminoacyl transfer RNA synthetase-interacting multifunctional protein 2; OE, overexpression; NC, negative control; ns, not significant; siRNA, small interfering RNA.