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. 2024 Aug 23;22:787. doi: 10.1186/s12967-024-05582-0

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Light and transmission electron microscopy (TEM) analysis of Achilles tendons of control and woozy mouse. (A and C) Toluidine blue stained semi thin-sections of the boundary between Achilles tendon (T) and the soleus muscle (mc) from heterozygous (SIL1^+/−) control (CTRL, A) and woozy (SIL1^−/−) mice (HOMO, C). The myotendinous junction (MTJ) is indicated by asterisk. (B and D) Representative images at TEM higher magnification of the connective tissue in control (CTRL, B) and woozy mice (HOMO, D), with tenocytes (Ten) arranged between the collagenous fibrils (Coll) of the ECM. Some organelles are visible (e.g. mitochondria, m) as well as cell debris (black arrow), and areas of degeneration (empty arrow)