Fig. 3. Circulating ceramide profiles are more reflective of the liver, not the intestine.

Lipidomic quantitation of individual ceramides (solid bars) in (A) super mesenteric serum and (B) cardiac serum or the (C) liver of rats fed either a control or an HFD. The following numbers of biological replicates were used (independent rats) per diet group in each experiment: (A to C) n = 6. Data are expressed as means ± SEM. **P < 0.01 and ***P < 0.001.