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. 2024 Aug 23;10(34):eadp5753. doi: 10.1126/sciadv.adp5753

Fig. 3. Cryo-EM structure of hCDCA7 bound at linker DNA.

Fig. 3.

(A) EMSA analyzing the interaction of hCDCA7264–371 C339S with nucleosomes carrying hemimethylated CpG at the indicated positions. (B) A composite cryo-EM map (top) and the model structure (bottom) of hCDCA7264–371 C339S (generated from AF2) bound to Nuc+75W shown in (A). The map corresponding to CDCA7 is colored purple except for the conserved C-terminal helix, which is colored orange.