Figure 4: DOX-correlated module proteins are enriched for distinct functions.

(A) The total number of enriched biological processes (adjusted P < 0.05) across DOX-correlated modules and their overlap between modules. Terms representing the top enriched processes are indicated. (B) Enrichment of proteins of different functional categories amongst DOX-correlated module proteins. Asterisk represents protein categories with a significant enrichment of module proteins (*P < 0.05). (C) Enrichment of proteins annotated by transcription factor binding domains amongst DOX-correlated module proteins. Grey shading indicates an infinite likelihood due to all transcription factor proteins with the particular binding domain being in only one module. (D) Top 20 most DOX-responsive transcription factors across DOX-correlated modules represented by log₂ fold change from the pairwise differential abundance test. (E) Enrichment of RNA binding protein (RBP) types amongst DOX-correlated module proteins. (F) Top 20 most DOX-responsive RBPs across DOX-correlated modules. (G) Enrichment of proteins annotated by enzymatic process amongst DOX-correlated module proteins. (H) Top 20 most DOX-responsive enzymes across DOX-correlated modules.