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ApoE4 expression disrupts endosomal maturation and ApoE2 increases lysosomal capacity. A-B. Bar plot displaying Δabundance (orange) and Δturnover (blue) of proteins detected in all experimental cohorts for significant* ontologies related to endolysosomal trafficking in the E2vsE3 comparison (A) and in the E4vsE3 comparison (B). C. Heatmap displaying % of proteins shared across the endolysosomal ontologies with significant* Δabundance. (*BH-PV < 0.05.
