Figure 1.

(A) Example components of a renal voxel with tissue (grey), tubules (blue), and vascular (red) components. (B) Simulated multi-gaussian diffusion over 100s within a 1mm diameter sphere. Three compartments are simulated of tissue (f=0.6, D = 0.002), renal tubules (f=0.3, D=0.02), and capillary network (f=0.1, D=0.08). (C) shows the simulated concentration of each compartment (grey, blue, red) over time as each diffuses out of the r=0.5mm sphere, with total concentration overlaid in black; the slowest diffusion is constant for the first four time points as the diffusion coefficient is so small that none have left the sphere yet. (D) shows the DWI multi b-value curve as a tri-exponential of the three compartments (black) along with corresponding individual curves from each (grey, blue, red). (E) Shows the spectrum of the simulated multi b-value curve and the fraction f and diffusion coefficient D of the three returned peaks. They are labeled as they correspond to each of the three original Gaussians.