Table 2.
Quantification of vascular and tubular flow in diseased allografts. Shown are examples of calculated vascular and tubular fD in ml/min per patient using spectral diffusion parameters for diagnostic groups of fibrosis (fibrosis as IFTA>0) and function (impaired allografts having eGFR < 45 ml/min/1.73m2 and normal/stable allografts having eGFR ≥ 45 ml/min/1.73m2). The mean CKD-EPI GFR of each group is included for relevant comparison. For reference, literature standard healthy renal blood flow for is 1 liter/min total54.
| Kidney Group | Mean vascular flow in ml/min | Mean tubular flow in ml/min | Mean ±stdev eGFR ml/min/1.72m2 |
|---|---|---|---|
| 1. Healthy volunteer (n=5) left kidney | 605±328 | 122±63 | >90 |
| 2. Healthy volunteer (n=5) right kidney | 489±344 | 122±72 | >90 |
| 3. Stable allograft (n=13) | 807±464 | 82±59 | 57.9±10.6 |
| 4. Allograft with impaired function and fibrosis (n=19) | 543±577 | 45±53 | 29.8±9.7 |
| 5. Allograft with impaired function and no fibrosis (n=7) | 688±534 | 33±35 | 29.2±12.4 |
| 6. Allograft with normal/stable function and fibrosis (n=15) | 526±661 | 36±56 | 59.1±15.2 |