Figure 5: How to map agnologous cell types and cell states across species.

(a) The objective is to align analogous cells (represented by points shaded in red and blue patches) across species, given pairs of single-cell datasets or even multiple single-cell datasets from different species. (b) The majority of methods align cells with similar expression patterns in homologs across a pair of species. (c) SATURN [98] stands out as the only method capable of aligning single-cell datasets from multiple species simultaneously. It first aggregates genes into synthesized genes using PLM [99]. These synthesized genes are then utilized to align cells across multiple species.