Figure 2. Longitudinal Biomarker Trajectories.

Longitudinal trajectories of (a) serum NfL; (b) serum pNfH; and (c) urinary p75^ECD . Y-axis shows percent change in each biomarker compared to baseline, plotted on a log scale. The faint grey dotted line illustrates the linear estimate of biomarker change over time. Error bars represent 95% confidence intervals (CI), widened at later time points due to participant attrition over time and fewer biomarker data available. NfL and pNfH were measured in duplicate; p75^ECD quantified with a median of 3 replicates. Single NfL and pNfH values from the 18-month visit of a single participant have been excluded (see footnote to Table 2 for detailed explanation).