Table 1b.
Baseline biomarker data
| Biomarker | N | Mean ±SD | Median (Q1, Q3) | Range |
|---|---|---|---|---|
|
| ||||
| Serum NfL (pg/mL) | 203 | 73.9 ± 47.0 | 67.9 (37.9, 92.5) | 9.1 – 214 |
| Serum pNfH (pg/mL) | 203 | 598 ± 718 | 267 (110, 924) | 3.4 – 4,177 |
|
| ||||
| Serum NfL/pNfH ratio | 203 | 0.52 ± 1.56 | 0.18 (0.09, 0.50) | 0.020 – 20.9 |
| Urinary p75ECD (ng/mg creatinine) | 160 1 | 5.54 ± 2.42 | 5.05 (3.93, 6.44) | 1.53 – 16.1 |
|
| ||||
| Serum uric acid (mg/dL) | 203 | 5.19 ± 1.31 | 5.00 (4.20, 6.20) | 2.60 – 8.90 |
|
| ||||
| Serum creatinine (mg/dL) | 203 | 0.78 ± 0.20 | 0.77 (0.66, 0.90) | 0.29 – 1.59 |
|
| ||||
| Serum albumin (g/dL) | 203 | 4.55 ± 0.34 | 4.50 (4.30, 4.80) | 3.60 – 5.80 |
|
| ||||
| Serum CRP (mg/dL) | 203 | 0.27 ± 0.35 | 0.10 (0.10, 0.50) | 0.10 – 2.30 |
|
| ||||
| Plasma miR-181a (UMI) | 201 | 451 ±208 | 418 (312, 552) | 124 – 1,699 |
| Plasma miR-181b (UMI) | 201 | 66.2 ± 31.4 | 61.2 (44.8, 79.7) | 13.8 – 263 |
| Plasma miR-181ab (UMI^2) | 201 | 34,663 ± 39,372 | 24,590 (13,638, 42,836) | 3,148 – 447,480 |
UMI = unique molecular identifier
1
Urinary p75ECD only available from a subset of study participants.