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Longitudinal biomarker trajectories
| Biomarker | Increase per month, relative to baseline | ||
|---|---|---|---|
| Mean | (95% CI) | P-value | |
| Serum NfL (pg/mL) 1 | 0.98% | (0.57%, 1.38%) | <0.0001 |
|
| |||
| Serum pNfH (pg/mL) 1 | 0.45% | (−0.12%, 1.03%) | 0.12 |
|
| |||
| Serum NfL/pNfH ratio | 0.44% | (−0.09%, 0.97%) | 0.10 |
|
| |||
| Urinary p75ECD (ng/mg creatinine) | 2.59% | (2.01%, 3.17%) | <0.0001 |
Values are unadjusted for core clinical covariates
One substantial outlier, from the 18-month visit (i.e. visit 5) of a participant, was excluded.
