Figure 4. Chicago plot showing the direction of associations with results of the SV genome-wide scan in 1,088 ROS/MAP participants across 24 AD/ADRD phenotypes.
A, Phenotypes are colored by common related categories. Solid-line represents the genome-wide significance of P < 5 × 10−8. The dashed line represents a suggestive threshold of P < 10−4. Phenotype labels are shown only for associations below the suggestive threshold. Prioritized associations (PMETA < 5 × 10−5 and no LD with SNPs) are highlighted in bold. B, List of 7 prioritized SV-trait associations under the conditions of PMETA < 5 × 10−3 for at least one ADRD phenotype, no LD with SNPs in their respective loci, and supporting evidence of the SV call in gnomAD. Bonferroni adjusted P-values are displayed in the heatmap. Asterisks indicate adj. P < 0.05.