Table 1.
Genomic inflation of genome wide association tests in each cohort and meta-analysis
| Phenotype | ROS () | MAP () | Meta-Analysis (ROS/MAP) () |
|---|---|---|---|
| Cognition | |||
| Alzheimer’s Dementia | 1.01 | 1.01 | 0.99 |
| Mild cognitive impairment | 1.01 | 0.99 | 0.98 |
| Global cognitive function | 1.00 | 0.73 | 0.89 |
| Cognitive decline | 1.02 | 1.02 | 0.97 |
| Cognitive resilience | 1.02 | 1.01 | 1.03 |
| Depression | |||
| Depressive symptoms (CES-D) | 0.67 | 1.03 | 1.01 |
| Major Depressive Disorder | 1.08 | 1.02 | 1.03 |
| Motor | |||
| Frailty | 0.59 | 0.99 | 1.02 |
| Motor functions | 0.90 | 1.01 | 0.94 |
| Global parkinsonian score | 0.91 | 0.85 | 1.00 |
| Pathology | |||
| NIA-Reagan diagnosis of AD | 1.01 | 1.03 | 0.99 |
| Global AD pathology | 0.99 | 1.00 | 0.99 |
| Beta-Amyloid | 1.01 | 1.00 | 1.01 |
| Tangle density | 1.03 | 0.99 | 0.99 |
| Diffuse plaques | 1.01 | 0.91 | 0.99 |
| Neuritic plaques | 1.01 | 1.02 | 1.00 |
| Neurofibrillary tangle | 1.01 | 0.86 | 0.92 |
| TDP-43 | 1.01 | 0.99 | 1.01 |
| Lewy Body disease | 0.99 | 1.00 | 1.00 |
| Vascular Pathology | |||
| Arteriolosclerosis | 1.03 | 0.96 | 0.99 |
| Cerebral Atherosclerosis | 1.03 | 0.99 | 1.00 |
| Cerebral amyloid angiopathy | 1.00 | 0.99 | 1.00 |
| Cerebral Infarctions (Gross) | 1.01 | 1.01 | 1.00 |
| Cerebral Infarctions (Micro) | 1.00 | 1.00 | 1.00 |