Table 2 -.
SVs associated with AD/ADRD traits with no LD with SNPs
| Phenotype | SV | MAF | ROS | MAP | Meta-Analysis (ROS/MAP) | ||||
|---|---|---|---|---|---|---|---|---|---|
| Beta (SE) | P | Beta (SE) | P | Beta (SE) | P | Gene | |||
| Cognitive resilience | DUP_267 chr1:206282705 (len:5,624bp) | 34.3% | 0.01 (0.01) | 1.27 × 10−1 | 0.02 (0.01) | 2.41 × 10−3 | 0.01 (0.00) | 1.02 × 10−3 | C1orf186 |
| Cognitive decline | DUP_267 chr1:206282705 (len:5,624bp) | 34.3% | 0.02 (0.01) | 3.90 × 10−2 | 0.02 (0.01) | 1.11 × 10−2 | 0.02 (0.01) | 1.28 × 10−3 | C1orf186 |
| Global cognition | DUP_267 chr1:206282705 (len:5,624bp) | 34.3% | 0.26 (0.12) | 2.96 × 10−2 | 0.29 (0.12) | 1.71 × 10−2 | 0.27 (0.08) | 1.51 × 10−3 | C1orf186 |
| Cerebral Atherosclerosis | DEL_17353 chr20:17103451 (len:-374bp) | 8.5% | −0.20 (0.09) | 2.41 × 10−2 | −0.22 (0.10) | 2.20 × 10−2 | −0.21 (0.07) | 1.58 × 10−3 | RNU6–27P |
| Lewy Body disease | DEL_21899 chr4:67382200 (len:-69bp) | 28.3% | 0.49 (0.22) | 2.44 × 10−2 | 0.46 (0.20) | 2.42 × 10−2 | 0.46 (0.15) | 1.73 × 10−3 | RPS23P3 |
| TDP-43 | DUP_2394 chr2:1284965 (len:342bp) | 42.4% | −0.70 (0.27) | 8.19 × 10−3 | −0.41 (0.22) | 6.40 × 10−2 | −0.53 (0.17) | 2.19 × 10−3 | SNTG2 |
| MDD | DEL_26626 chr6:108266112 (len:-323bp) | 28.2% | 0.78 (0.36) | 2.85 × 10−2 | 0.71 (0.32) | 2.81 × 10−2 | 0.76 (0.24) | 2.31 × 10−3 | SEC63 |
| Micro-chronic cerebral infarctions | DEL_28995 chr7:128309211 (len:-349bp) | 8.6% | −0.10 (0.25) | 6.98 × 10−1 | 0.95 (0.26) | 2.87 × 10−4 | 0.40 (0.18) | 4.29 × 10−3 | RP11–274B21.5 |
| Cerebral amyloid angiopathy | DEL_9454 chr15:35009016 (len:-372bp) | 5.2% | 0.36 (0.14) | 8.63 × 10−3 | 0.19 (0.13) | 1.27 × 10−1 | 0.26 (0.09) | 4.40 × 10−3 | GJD2 |