Table 3.
Summary of studies examining CFC phenotypes in littermate and non-littermate Fmr1 KO mice. (Studies examining CFC (only context, no cued or trace conditioning) in Fmr1 KO mice were subdivided into two groups: (i) littermate and (ii) non-littermate mice.)
| CFC phenotype | studies | ref. | mouse (background); notes | |
|---|---|---|---|---|
| littermate | no change | Dobkin et al. 2000 | [77] | Fmr1 KO (FVB-129 and C57BL/6-129) |
| van Dam et al. 2000 | [73] | Fmr1 KO (C57BL/6J) | ||
| Spencer et al. 2006 | [44] | Fmr1 KO (C57BL/6J); littermate: Fmr1+/− mother and Fxr2−/y father | ||
| Uutela et al. 2012 | [75] | Fmr1 KO (C57BL/6J); littermate: Fmr1+/− mother and BDNF+/− father | ||
| Nolan et al. 2022 | [76] | Fmr1 KO (FVB-129) | ||
| decrease | Paradee et al. 1999 | [54] | Fmr1 KO (C57BL/6J) | |
| Baker et al. 2010 | [70] | Fmr1 KO (albino C57BL/6J) | ||
| Reyes et al. 2021 | [72] | Fmr1 KO2 (C57BL/6J) | ||
| non-littermate | no change | — | — | — |
| decrease | Ding et al. 2014 | [71] | Fmr1 KO (C57BL/6J); male and female | |
| Martinez & Tejada-Simon 2018 | [39] | Fmr1 KO (FVB-129) |