Table 2.
Main results from genome-wide interaction scans of red meat consumption
| Meat intake variable | SNP | Chr | BP Position | Gene | Ref | Alt | Alt Allele Freq (1000G EUR) | Method | P-value G | P-value GxE | P-value 3-df |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||||
| Red meat | rs4871179 | 8 | 122247679 | Downstream HAS2 | C | G | 0.33 | Joint test (3-df) | 3.99E-04 | 1.00E-06 | 3.05E-08 |
| Red meat | rs35352860 | 18 | 46453754 | SMAD7 | C | T | 0.26 | Two-step | 4.75E-21 | 2.0E-8 | 7.16E-23 |
SNP, single nucleotide polymorphism; Chr, chromosome; df, degrees of freedom; BP Position, base pair position based on NCBI Build37.
Notes: Imputed SNPs were coded as expected gene dosage. Multiplicative interaction terms were modelled as the product of red meat and each SNP of interest. All statistical tests were two-sided. Models were adjusted for age, sex, study, total energy intake (kcal/day), and the first three principal components to account for ancestry.