Skip to main content
. 2024 Jul 18;9(16):e177152. doi: 10.1172/jci.insight.177152

Figure 2. Individuals with higher GAA repeat length are more likely to experience higher maximal EF.

Figure 2

(A and B) Frequency distribution of maximal EFs sorted by GAA (GAA1) repeat length on the shorter allele (n = 315). Curves generated by LOWESS regression with coarse smoothing on frequency distribution of maximum EF (bin size = 2). Simulated healthy control data generated by setting mean and SD with gaussian frequency based on ref. 56. (C) Posterior wall thickness at diastole at maximal EF (n = 315) compared with simulated healthy control data (57). (D) Individual patient EF range recorded throughout 6+ years sorted by GAA repeat length (n = 106). Peak EF is noted with pink circles, and minimum EF is noted with blue circles. Dotted lines represent minimum and maximum observed EFs in adolescents.