Table 1.

Population, Interventions, Comparisons, Outcomes, and Study (PICOS) design selection criteria

Inclusion	Exclusion
Population
Adults with RRMM	Untreated MM (i.e., first-line treatment setting) Any other population
Interventions/comparators
Any	Economic evaluations exclusively for diagnostic testing or patient management strategies
Outcomes
Model conceptualization  Model structure  Uncertainty assessment  Validation  Transparency	Any other outcome
Study design and publication type
Economic evaluations (cost-effectiveness, cost-utility, cost consequence, cost-minimization, and cost-benefit analysis)  SLRs/NMAs (to be hand searched for relevant studies)	Clinical trials Non-SLRs Conference abstracts Budget impact analysis Non-human studies Pharmacodynamic studies Preclinical studies Case reports Commentaries, editorials, and letters Consensus reports Observational RWE studies
Additional limits
Date of publication
Full texts since 2014  HTA submissions since 2018	Full-text references published prior to 2014 HTA submissions published prior to 2018
Language
English	Non-English articles

HTA health technology assessment, MM multiple myeloma, NMA network meta-analysis, RRMM relapsed/refractory multiple myeloma, RWE real-world evidence, SLR systematic literature review