Table 1.

NMR data for novel apicidin L (4)

C5D5N
	Apicidin L
Position	δC/ppm, type	δH/ppm, m, (J in Hz)
N-methoxytryptophane
NH		9.96, d (6.7)
1	175.1, C
2	62.5, CH	4.48, dt (9.6, 7.0)
3	26.0, CH2	4.24–4.14, m 3.87, dd (14.5, 7.3)
4	108.7, C
4a	124.7, C
5	119.9, CH	7.74, d (7.9)
6	120.7, CH	7.18, t (7.0)
7	123.4, CH	7.36–7.30, m
8	109.4, CH	7.53, d (8.1)
8a	133.4, C
9	123.3, CH	7.50–7.43, m
10	66.2, CH3	3.91, s
2-amino-8-hydroxy-octanoic acid
NH′		7.86, d (10.0)
1′	176.7, C
2′	55.8, CH	4.75, ddd (10.0, 8.4, 6.8)
3′	30.9, CH2	2.06–1.89, m 1.66–1.60, m
4′	26.7, CH2	1.30–1.18, m
5′	29.9, CH2	1.30–1.18, m
6′	26.6, CH2	1.50–1.31, m
7′	34.1, CH2	1.66–1.60, m
8′	62.4, CH2	3.81, t (6.5)
OH′		5.10, s
proline
1″	172.4, C
2″	58.6, CH	5.03–4.95, m
3″	25.5, CH2	2.38–2.30, m 1.50–1.38, m
4″	25.4, CH2	2.11, dt (18.0, 6.8) 1.60–1.51, m
5″	47.2, CH2	4.11, dd (9.6, 3.9) 3.35, dt (10.1,8.1)
Phenylalanine
NH‴		8.55, d (10.1)
1‴	173.9, C
2‴	54.3, CH	5.61, ddd (10.2, 8.7, 6.8)
3‴	37.2, CH2	3.54, dd (13.6, 8.7) 3.28, dd (13.6, 6.8)
4‴	138.6, C
5/9‴	130.2, CH	7.50–7.43, m
6/8‴	129.4, CH	7.36–7.30, m
7‴	127.5, CH	7.25, t (8.1)

¹H NMR was recorded at 600 MHz, ¹³C NMR was recorded at 150 MHz in C₅D₅N