Table 1.
GRCh38 chromosome 11 bin | ||||||||
---|---|---|---|---|---|---|---|---|
Population | Gene | – | 1,220,000 | 1,230,000 | 1,240,000a | 1,250,000a | 1,260,000 | 1,270,000 |
AFR | MUC5B | Tajima’s D | −1.09 | −1.47 | −1.84c,d | −1.87c,d | −1.94c,d | −2.10c,d |
# SNPs | 180 | 162 | 444 | 279 | 209 | 248 | ||
EUR | MUC5B | Tajima’s D | −0.44 | −0.42 | −1.49 | −1.39 | −1.56 | −1.60 |
# SNPs | 122 | 81 | 356 | 191 | 73 | 103 | ||
SAS | MUC5B | Tajima’s D | −0.55 | −0.96 | −1.76b | −1.77b | −1.59 | −1.65 |
# SNPs | 140 | 100 | 328 | 188 | 85 | 102 | ||
EAS | MUC5B | Tajima’s D | −0.25 | −0.49 | −1.58 | −1.69b | −2.13c,d | −1.91b |
# SNPs | 109 | 62 | 189 | 109 | 79 | 83 | ||
AMR | MUC5B | Tajima’s D | −0.46 | −1.22 | −1.84 | −1.87b | −1.95b | −1.90b |
# SNPs | 130 | 110 | 353 | 201 | 108 | 122 |
Bin sizes of 10 kbp were used to compare values to the autosome-wide distribution per population in the 1KG cohort.19
Corresponds to bin containing VNTR sequence.
Bottom 10% of autosome-wide Tajima’s D values.
Bottom 5% of autosome-wide Tajima’s D values.
Significant at α = 0.05 after permutation testing.