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. 2024 Aug 23;15:7265. doi: 10.1038/s41467-024-50970-1

Fig. 4. CGRP is essential for capsaicin-induced exacerbation of rosacea-like dermatitis.

Fig. 4

A Representative whole-mount image of capsaicin-treated skin from Nav1.8RFP mice with LL37 injection stained for CGRP. B Representative image of CGRP expression in the skin of healthy volunteer (HS) and rosacea patients (Rosacea). C Diagram of the experimental paradigm in (D–G). Mice were co-administered capsaicin with CGRP8-37 on day −1 before intradermal injection of PBS or LL37. D Representative photo and HE staining and (E) The redness score, area of erythema and skin thickness of skin tissues (n = 4 or 6 for each group) and (F) The mRNA levels of rosacea-characteristic factors (n = 6 for each group) and (G) The CD4+ T cells infiltration and the CD31+ microvascular in the skin of CGRP8-37 and capsaicin-treated mice after LL37 injection (n = 5 for each group). Data represent the mean ± SEM. ns, p > 0.05. Two-way ANOVA with Bonferroni’s post hoc test was used.