Fig. 5. CGRP-induced dermatitis aggravation in rosacea-like mice.

A Diagram of the experimental paradigm in (A–E). Mice were treated with CGRP and intradermal injection of PBS or LL37. B Representative photo and HE staining and (C) The redness score, area of erythema and skin thickness (n = 4 for each group) and (D) The mRNA levels of rosacea-characteristic factors (n = 4 for each group) and E, The CD4⁺ T cells infiltration and the CD31⁺ microvascular in the skin of vehicle or CGRP-treated mice after LL37 or PBS injection (n = 4 for each group). C–E Data represent the mean ± SEM. ns, p > 0.05. Two-way ANOVA with Bonferroni’s post hoc test was used.