Fig. 7. Sensory nerve-secreted CGRP activates γδ T cells directly.

A Diagram of the experimental paradigm in (A–E). Capsaicin or vehicle on day −1 before intradermal injection of LL37 in WT or Tcrd^−/− mice. B Representative macroscopic images and HE-stained sections and C The redness score, area of erythema and skin thickness of skin tissues in vehicle or capsaicin-treated WT or Tcrd^−/− mice after LL37 injection (n = 5 mice for each group). D The mRNA levels of rosacea-characteristic factors and E CD4⁺ T cells infiltration and CD31⁺ microvasculature in the skin of vehicle- or capsaicin-treated WT or Tcrd^−/− mice after LL37 injection (n = 4 for each group). C–E Data represent the mean ± SEM. ns, p > 0.05. Two-way ANOVA with Bonferroni’s post hoc test was used.