Fig. 5. Spatial overlap between effect maps of sex differences for the microstructural gradient, profile mean, and profile skewness.

Transcriptomic maps of genes are sorted by categories: sex hormone synthesis-related genes, and androgen, estrogen, and progesterone receptor-related genes. We test for spatial specificity by comparing against the principal component of all genes (baseline). Shades of red represent positive r-values, shades of blue represent negative correlations; circle size and shading indicate size of correlation. Values with significant p-values (p < 0.05) after permutation spin-testing are marked with a black outline (one-sided). Note that no correlation is significant when accounting for multiple testing at an FDR-threshold. Source data are provided as a Source Data file.