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. Author manuscript; available in PMC: 2024 Aug 24.
Published in final edited form as: Allergy. 2022 Nov 5;78(4):1047–1059. doi: 10.1111/all.15561

FIGURE 5.

FIGURE 5

RNA-sequencing results of scalp samples in alopecia areata (AA) by atopic background (determined as personal/family history of atopy or elevated serum IgE levels ≥200 IU/ml). Lesional transcriptome of all differentially expressed genes (DEGs) in atopic participants only presented as a heatmap with respective number of participants at the bottom (A), and as a plot indicating percent of improvement in DEGs during treatment (B). Blue and Red boxes denote down- and upregulated DEGs, respectively, across treatment arms during the trial in atopic participants, with a dashed line representing non-lesional scalp at baseline (C). Immune gene-set presented as a heatmap stratified by atopic background, including a red box highlighting genes related with dupilumab’s mechanism of action (D). BL, baseline; LS, lesional; NL, non-lesional; OLE, open label extension; W12, week 12; W24, week 24; W48, week 48. +/*/**/*** denote significance (p < .1/.05/.01/.001, respectively).