Table 2.

Multivariate Cox proportional hazards model analysis of factors associated with progression-free survival

	HR	95% CI	P-value
Sex (Male)	1.20	0.71–2.03	0.498
Age (≥ 75)	1.19	0.81–1.77	0.375
PS (≥ 2)	0.98	0.52–1.72	0.946
Smoking (Yes)	1.12	0.67–1.83	0.671
EGFR (L858R)	1.59	1.08–2.35	0.019*
Brain metastasis	1.48	0.96–2.23	0.076**
Pleural effusion	1.29	0.87–1.91	0.198
Liver metastasis	1.88	0.97–3.42	0.061**
Bone metastasis	1.45	0.95–2.17	0.081**

*P < 0.05, **P < 0.10

HR, hazard ratio; CI, confidence interval; PS, performance status; EGFR, epidermal growth factor receptor