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. 2024 Aug 24;23:266. doi: 10.1186/s12944-024-02231-9

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Microbiome-targeted therapies and herbal rosavin impact on hepatic steatosis, inflammation, and fibrosis assessed using H&E staining. Histological examinations revealed (A) Normal group: normal architecture. B NASH-12 wk and (C) NASH-9wk groups: showed severe parenchymal damage, ballooned liver cells, and micro and macro-vesicular steatosis. Additionally, the NASH-12wk group showed substantial fibrosis. Notable histological improvements in steatosis, inflammation, fibrosis, and NASH score in (D) FUS, (E) INU, (F) FUS + INU, (G) Mutaflor, (H) Kefir, (I) Ros-10, (J) Ros-20 and (K) Ros-30 treated groups (Magnifications: × 100)