Table 3.
Correlation of Ganglion Cell Layer + Inner Plexiform Layer (GCL + IPL) and Circumpapillary Retinal Nerve Fiber Layer (cRNFL) Across Different Stages of Glaucoma
| Glaucoma field defect severity | Odds Ratio (95% CI) | P-value | |||
|---|---|---|---|---|---|
| None n = 43 | Mild n = 40 | Moderate-to-Severe n = 39 | |||
| Macular Ganglion Cell Analysis | |||||
| Average GCL + IPL | 81 (76 to 84.5) | 71 (65.75 to 78) | 59 (54 to 65.5) | 0.83 (0.79 to 0.88) | 0.000* |
| Minimum GCL + IPL | 77 (73 to 82) | 65.5 (59 to 76) | 52 (47 to 56.5) | 0.87 (0.83 to 0.9) | 0.000* |
| Sectoral GCL + IPL | |||||
| Superior | 82 (77 to 86) | 71 (60 to 79) | 62 (54 to 69.5) | 0.89 (0.86 to 0.92) | 0.000* |
| Superonasal | 84 (79 to 87.5) | 73 (64.75 to 80) | 64 (56.5 to 72) | 0.89 (0.86 to 0.92) | 0.000* |
| Superotemporal | 79 (76.5 to 84) | 69 (61 to 78) | 56 (54.5 to 68) | 0.87 (0.84 to 0.91) | 0.000* |
| Inferior | 80 (73.5 to 83.5) | 68.5 (64 to 77.25) | 59 (52.5 to 65.5) | 0.87 (0.83 to 0.9) | 0.000* |
| Inferonasal | 82 (76 to 85) | 70 (62.75 to 80) | 60 (54 to 68) | 0.86 (0.82 to 0.9) | 0.000* |
| Inferotemporal | 81 (77.5 to 84) | 74 (67.75 to 79.25) | 57 (50.5 to 66) | 0.87 (0.83 to 0.9) | 0.000* |
| Circumpapillary RNFL | |||||
| Sectoral RNFL | |||||
| Superior Quadrant | |||||
| S | 107 (97 to 132.5) | 101 (81.75 to 121.25) | 72 (61.5 to 90) | 0.83 (0.79 to 0.87) | 0.000* |
| SN | 98 (86.5 to 111.5) | 93.5 (81.25 to 104) | 71 (63.5 to 79.5) | 0.97 (0.96 to 0.98) | 0.000* |
| ST | 134 (115.5 to 144) | 111.5 (92.5 to 131.25) | 68 (61.5 to 87) | 0.95 (0.93 to 0.97) | 0.000* |
| Inferior Quadrant | |||||
| I | 138 (118 to 150.5) | 116 (101 to 134.25) | 68 (57 to 81.5) | 0.95 (0.94 to 0.97) | 0.000* |
| IN | 95 (81.5 to 110) | 87 (70.75 to 98.25) | 62 (56.5 to 72.5) | 0.94 (0.93 to 0.96) | 0.000* |
| IT | 137 (127.5 to 148) | 117 (96.75 to 135.5) | 70 (54 to 82) | 0.94 (0.92 to 0.96) | 0.000* |
| Nasal Quadrant | |||||
| N | 62 (54 to 65) | 61 (55.75 to 71.25) | 59 (54 to 66.5) | 0.94 (0.92 to 0.95) | 0.000* |
| NU | 82 (71.5 to 93.5) | 77 (69.75 to 84.25) | 67 (64 to 77) | 1.01 (0.99 to 1.03) | 0.265 |
| NL | 64 (59 to 69.5) | 64 (56 to 68) | 59 (53 to 63) | 0.95 (0.93 to 0.98) | 0.000* |
| Temporal Quadrant | |||||
| T | 57 (50 to 63) | 48.5 (42.75 to 56.25) | 45 (41 to 55) | 0.98 (0.95 to 1.01) | 0.174 |
| TU | 87 (73 to 96.5) | 67 (59.25 to 86.25) | 52 (43 to 65.5) | 0.95 (0.92 to 0.98) | 0.001* |
| TL | 67 (58.5 to 73.5) | 57.5 (50 to 64.5) | 52 (43.5 to 62.5) | 0.94 (0.92 to 0.96) | 0.000* |
Note: *Statistically significant.