Table 4.
APC-IE model of Incidence and mortality relative risks of leukaemia due to age, period, and cohort effects in global
| Incidence |
Mortality |
|||||
|---|---|---|---|---|---|---|
|
Factor
|
RR (95% CI)
|
P-value
|
RR (95% CI)
|
P-value
|
||
| Age in years |
|
|
|
|
||
|
0
|
2.42 (2.41, 2.43) |
<0.01 |
1.36 (1.35, 1.37) |
<0.01 |
||
|
5
|
0.91 (0.90, 0.91) |
<0.01 |
0.62 (0.62, 0.63) |
<0.01 |
||
|
10
|
0.49 (0.48, 0.49) |
<0.01 |
0.46 (0.45, 0.46) |
<0.01 |
||
|
15
|
0.40 (0.39, 0.40) |
<0.01 |
0.43 (0.42, 0.43) |
<0.01 |
||
|
20
|
0.34 (0.33, 0.34) |
<0.01 |
0.36 (0.35, 0.36) |
<0.01 |
||
|
25
|
0.31 (0.30, 0.31) |
<0.01 |
0.32 (0.32, 0.33) |
<0.01 |
||
|
30
|
0.30 (0.29, 0.30) |
<0.01 |
0.31 (0.31, 0.32) |
<0.01 |
||
|
35
|
0.39 (0.38, 0.39) |
<0.01 |
0.35 (0.34, 0.35) |
<0.01 |
||
|
40
|
0.39 (0.39, 0.40) |
<0.01 |
0.39 (0.39, 0.40) |
<0.01 |
||
|
45
|
0.50 (0.50, 0.51) |
<0.01 |
0.46 (0.45, 0.46) |
<0.01 |
||
|
50
|
0.66 (0.66, 0.67) |
<0.01 |
0.59 (0.58, 0.59) |
<0.01 |
||
|
55
|
0.88 (0.88, 0.89) |
<0.01 |
0.79 (0.78, 0.79) |
<0.01 |
||
|
60
|
1.16 (1.15, 1.16) |
<0.01 |
1.08 (1.07, 1.08) |
<0.01 |
||
|
65
|
1.46 (1.45, 1.47) |
<0.01 |
1.48 (1.47, 1.49) |
<0.01 |
||
|
70
|
1.94 (1.93, 1.95) |
<0.01 |
2.05 (2.04, 2.06) |
<0.01 |
||
|
75
|
2.38 (2.36, 2.39) |
<0.01 |
2.72 (2.70, 2.73) |
<0.01 |
||
|
80
|
2.67 (2.66, 2.68) |
<0.01 |
3.44 (3.42, 3.46) |
<0.01 |
||
|
85
|
3.43 (3.41, 3.45) |
<0.01 |
4.73 (4.70, 4.76) |
<0.01 |
||
|
90
|
3.78 (3.75, 3.81) |
<0.01 |
5.63 (5.59, 5.68) |
<0.01 |
||
|
95
|
6.26 (6.20, 6.33) |
<0.01 |
6.96 (6.87, 7.05) |
<0.01 |
||
| Period |
|
|
|
|
||
|
1990
|
0.90 (0.89, 0.90) |
<0.01 |
0.98 (0.98, 0.99) |
<0.01 |
||
|
1995
|
0.95 (0.95, 0.96) |
<0.01 |
1.00 (0.99, 1.00) |
0.00 |
||
|
2000
|
0.99 (0.98, 0.99) |
<0.01 |
1.00 (0.99, 1.00) |
0.01 |
||
|
2005
|
1.01 (1.00, 1.01) |
<0.01 |
0.99 (0.98, 1.00) |
<0.01 |
||
|
2010
|
1.06 (1.05, 1.06) |
<0.01 |
1.00 (1.00, 1.01) |
0.01 |
||
|
2015
|
1.12 (1.11, 1.12) |
<0.01 |
1.03 (1.03, 1.04) |
<0.01 |
||
| Cohort |
|
|
|
|
||
|
1895
|
1.38 (1.32, 1.44) |
<0.01 |
1.60 (1.52, 1.67) |
<0.01 |
||
|
1900
|
1.40 (1.37, 1.43) |
<0.01 |
1.62 (1.58, 1.65) |
<0.01 |
||
|
1905
|
1.44 (1.42, 1.46) |
<0.01 |
1.64 (1.61, 1.66) |
<0.01 |
||
|
1910
|
1.51 (1.50, 1.53) |
<0.01 |
1.68 (1.66, 1.69) |
<0.01 |
||
|
1915
|
1.53 (1.52, 1.54) |
<0.01 |
1.69 (1.68, 1.70) |
<0.01 |
||
|
1920
|
1.52 (1.51, 1.53) |
<0.01 |
1.69 (1.67, 1.70) |
<0.01 |
||
|
1925
|
1.51 (1.50, 1.52) |
<0.01 |
1.67 (1.66, 1.68) |
<0.01 |
||
|
1930
|
1.45 (1.44, 1.46) |
<0.01 |
1.61 (1.60, 1.63) |
<0.01 |
||
|
1935
|
1.39 (1.38, 1.40) |
<0.01 |
1.54 (1.52, 1.55) |
<0.01 |
||
|
1940
|
1.34 (1.33, 1.35) |
<0.01 |
1.46 (1.45, 1.47) |
<0.01 |
||
|
1945
|
1.28 (1.27, 1.29) |
<0.01 |
1.38 (1.37, 1.39) |
<0.01 |
||
|
1950
|
1.23 (1.22, 1.24) |
<0.01 |
1.29 (1.28, 1.30) |
<0.01 |
||
|
1955
|
1.16 (1.15, 1.17) |
<0.01 |
1.19 (1.18, 1.20) |
<0.01 |
||
|
1960
|
1.10 (1.09, 1.10) |
<0.01 |
1.08 (1.07, 1.09) |
<0.01 |
||
|
1965
|
1.09 (1.08, 1.10) |
<0.01 |
1.02 (1.01, 1.03) |
<0.01 |
||
|
1970
|
1.03 (1.03, 1.04) |
<0.01 |
0.94 (0.93, 0.95) |
<0.01 |
||
|
1975
|
0.97 (0.96, 0.97) |
<0.01 |
0.85 (0.84, 0.86) |
<0.01 |
||
|
1980
|
0.90 (0.89, 0.90) |
<0.01 |
0.77 (0.76, 0.78) |
<0.01 |
||
|
1985
|
0.85 (0.84, 0.86) |
<0.01 |
0.72 (0.71, 0.73) |
<0.01 |
||
|
1990
|
0.81 (0.80, 0.81) |
<0.01 |
0.67 (0.67, 0.68) |
<0.01 |
||
|
1995
|
0.66 (0.66, 0.67) |
<0.01 |
0.57 (0.57, 0.58) |
<0.01 |
||
|
2000
|
0.54 (0.54, 0.55) |
<0.01 |
0.49 (0.48, 0.49) |
<0.01 |
||
|
2005
|
0.45 (0.44, 0.45) |
<0.01 |
0.41 (0.41, 0.42) |
<0.01 |
||
|
2010
|
0.37 (0.37, 0.38) |
<0.01 |
0.35 (0.34, 0.35) |
<0.01 |
||
|
2015
|
0.31 (0.31, 0.32) | <0.01 |
0.29 (0.28, 0.30) | <0.01 | ||
APC-IE – age-period-cohort with intrinsic estimator, CI – confidence interval, RR – relative risk