Table 1.

TNF-α-targeting DNA aptamer, non-aptameric scrambled oligodeoxyribonucleotide and their conjugates with PEG

Aptamer	Nucleotide sequence, 5’-3’
PEG-aptTNF-α	PEG-NH2-(CH2)6-GCG CCA CTA CAG GGG AGC TGC CAT TCG AAT AGG TGG GCC GCTinv
aptTNF-α	NH2-(CH2)6-GCG CCA CTA CAG GGG AGC TGC CAT TCG AAT AGG TGG GCC GCTinv
PEG-Scr	PEG-NH2-(CH2)6-AGA GGC GGT ATG ACC AGG CTA ATC GGC CGA GCC TCC GTG CGTinv
Scr	NH2-(CH2)6-AGA GGC GGT ATG ACC AGG CTA ATC GGC CGA GCC TCC GTG CGTinv

PEG – 40 kDa polyethylene glycol residue;

T_inv – 3’-terminal residue of thymidine linked to the adjacent nucleotide with a 3’–3’ phosphodiester bond.