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. 2024 Aug 12;18:1436156. doi: 10.3389/fnhum.2024.1436156

Table 3.

Neural activity observed during the startle habituation using linear temporal modulator across the whole sample.

Brain region Hemisphere MNI coordinates T k p FWE
x y z
Changes in BOLD response amplitude across time
ROI analysis
Thalamus R 12 −22 18 3.94 9 0.052
L −16 −24 18 4.24 4 0.026
Whole brain analysis
Cluster: caudate and thalamus R 4 4 8 6.73 181 0.013
Cluster: caudate, thalamus, cingulate gyrus, and hippocampus L −14 −26 22 5.22 153 0.024
Positive association with startle habituation and linear change in BOLD response
ROI analysis
Thalamus R 22 −26 6 4.03 14 0.042
L 10 −32 6 3.46 2 0.150a
Whole brain analysis
Cluster: insula and thalamus R 30 −26 8 5.24 144 0.029
Cluster: parietal cortex, insula, superior temporal gyrus, hippocampus and caudate L −46 −36 20 5.05 531 <0.001
Negative association with startle habituation and linear change in BOLD response
Whole brain analysis
Cluster: frontal lobe extending to middle and inferior frontal gyrus L −28 10 38 4.88 320 0.001
Cluster: putamen extending to insula and temporal gyrus R 28 4 −8 4.14 120 0.052
Cluster: posterior cingulate gyrus extending to occipital gyrus R 4 −60 10 4.06 135 0.036
Cluster: frontal lobe extending to medial frontal gyrus L −12 −20 50 4.19 145 0.029
Cluster: inferior frontal gyrus extending to insula 52 4 10 4.10 101 0.083a
a

Does not survive FWE corrections.