Table 3.
Neural activity observed during the startle habituation using linear temporal modulator across the whole sample.
| Brain region | Hemisphere | MNI coordinates | T | k | p FWE | ||
|---|---|---|---|---|---|---|---|
| x | y | z | |||||
| Changes in BOLD response amplitude across time | |||||||
| ROI analysis | |||||||
| Thalamus | R | 12 | −22 | 18 | 3.94 | 9 | 0.052 |
| L | −16 | −24 | 18 | 4.24 | 4 | 0.026 | |
| Whole brain analysis | |||||||
| Cluster: caudate and thalamus | R | 4 | 4 | 8 | 6.73 | 181 | 0.013 |
| Cluster: caudate, thalamus, cingulate gyrus, and hippocampus | L | −14 | −26 | 22 | 5.22 | 153 | 0.024 |
| Positive association with startle habituation and linear change in BOLD response | |||||||
| ROI analysis | |||||||
| Thalamus | R | 22 | −26 | 6 | 4.03 | 14 | 0.042 |
| L | 10 | −32 | 6 | 3.46 | 2 | 0.150a | |
| Whole brain analysis | |||||||
| Cluster: insula and thalamus | R | 30 | −26 | 8 | 5.24 | 144 | 0.029 |
| Cluster: parietal cortex, insula, superior temporal gyrus, hippocampus and caudate | L | −46 | −36 | 20 | 5.05 | 531 | <0.001 |
| Negative association with startle habituation and linear change in BOLD response | |||||||
| Whole brain analysis | |||||||
| Cluster: frontal lobe extending to middle and inferior frontal gyrus | L | −28 | 10 | 38 | 4.88 | 320 | 0.001 |
| Cluster: putamen extending to insula and temporal gyrus | R | 28 | 4 | −8 | 4.14 | 120 | 0.052 |
| Cluster: posterior cingulate gyrus extending to occipital gyrus | R | 4 | −60 | 10 | 4.06 | 135 | 0.036 |
| Cluster: frontal lobe extending to medial frontal gyrus | L | −12 | −20 | 50 | 4.19 | 145 | 0.029 |
| Cluster: inferior frontal gyrus extending to insula | 52 | 4 | 10 | 4.10 | 101 | 0.083a | |
Does not survive FWE corrections.