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. 2024 Aug 12;15:1360587. doi: 10.3389/fphar.2024.1360587

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Copyright © 2024 Liu, Zhao, Liu, Wu, Li, Fu, Yang and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagram of the molecular mechanism for the present study. Shikonin may induce colon cancer cell senescence by downregulating CDKN2A and CXCL8 and suppress colon cancer development.