TABLE 1.

Principles and advantages and disadvantages of scutellarin extraction methods.

Extraction	Methods Basic	Advantages	Disadvantages	Refs
Solvent Extraction	Solvent is used to dissolve scutellarin in the plant material and the active metabolite is extracted through an infusion process	Simple operation and low equipment requirement	Extraction efficiency is low and time consuming	Yang et al. (2019b)
Ultrasonic-assisted extraction	Utilizing the cavitation effect of ultrasonic waves to accelerate the contact between the plant material and the solvent and improve the extraction efficiency	Short time and high extraction efficiency	Specialized ultrasonic extraction equipment is required	Xiang and Wu (2017)
Microwave-assisted extraction	Utilizes microwave energy to heat the solvent and plant material to promote the release and dissolution of active metabolites	High extraction speed and low energy consumption	Requires specialized microwave extraction equipment	Li et al. (2015)
Supercritical fluid extraction	Extraction of Scutellarin from plant materials under high pressure using supercritical CO2 as a solvent	Highly efficient and environmentally friendly, able to maintain the biological activity of Scutellarin	Expensive equipment and complicated operation	Yang and Wei (2018), Yang et al. (2019a)