Table 3.
Top 10 featured risk SNPs from the best-performing Elastic Net SNP model, UCLA ATLAS sample, stratified by genetic ancestry
| rsID | CHR | POS | Variable Importance (95% CI) | Nearest Gene | AD EUR | AD AFR | AD multi | LBD | PD | PSP | Stroke |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Hispanic Latino American ancestry (HLA) | |||||||||||
| rs429358 | 19 | 44908684 | 0.089 (0.02, 0.11) | APOE | x | ||||||
| rs2075650 | 19 | 44892362 | 0.089 (0.02, 0.11) | TOMM40 | x | x | x | ||||
| rs483082 | 19 | 44912921 | 0.07 (0.017, 0.086) | APOC1 | x | x | |||||
| rs157581 | 19 | 44892457 | 0.065 (0.014, 0.079) | TOMM40 | x | x | |||||
| rs412776 | 19 | 44876259 | 0.057 (0.016, 0.066) | NECTIN2 | x | x | |||||
| rs62120578 | 19 | 44713297 | 0.053 (0.022, 0.061) | CTB-171A8.1 | x | ||||||
| rs4803765 | 19 | 44855191 | 0.048 (0.015, 0.056) | NECTIN2 | x | ||||||
| rs80100206 | 4 | 705856 | 0.042 (0.02, 0.046) | PCGF3 | x | ||||||
| rs6857 | 19 | 44888997 | 0.038 (0.011, 0.042) | NECTIN2 | x | ||||||
| rs2276412 | 11 | 121590137 | 0.037 (0.018, 0.039) | SORL1 | x | ||||||
| African American ancestry (AA) | |||||||||||
| rs2627641 | 19 | 45205500 | 0.096 (0.077, 0.099) | BLOC1S3 | x | ||||||
| rs8073976 | 17 | 44955857 | 0.079 (0.065, 0.082) | C1QL1 | x | ||||||
| rs77283277 | 7 | 143386852 | 0.076 (0.063, 0.079) | ZYX | x | ||||||
| rs429358 | 19 | 44908684 | 0.071 (0.059, 0.074) | APOE | x | ||||||
| rs2075650 | 19 | 44892362 | 0.068 (0.056, 0.071) | TOMM40 | x | x | x | ||||
| rs73936967 | 19 | 44890485 | 0.064 (0.053, 0.066) | TOMM40 | x | ||||||
| rs13032148 | 2 | 127107524 | 0.063 (0.053, 0.065) | BIN1 | x | x | |||||
| rs71352239 | 19 | 44926286 | 0.056 (0.047, 0.057) | APOC1P1 | x | x | x | ||||
| rs435380 | 19 | 44903861 | 0.041 (0.037, 0.042) | TOMM40 | x | x | |||||
| rs11223641 | 11 | 133950127 | 0.041 (0.037, 0.041) | IGSF9B | x | ||||||
AD Alzheimer’s Disease, AFR African American, CI confidence interval, EUR European, LBD Lewy body dementia, PD Parkinson’s disease, PRS Polygenic Risk Score, PSP progressive supranuclear palsy, SNP Single-Nucleotide Polymorphism.
Note: SNPs marked in bold are overlapped SNPs identified by both samples.