TABLE 3.
Significant clusters of MD, RD, and AD with a size of ≥50 voxels.
| Cluster | Directionality | Number of voxels | p‐Value (max.) | MNI‐coordinates, region (max.) a | Subcomponents a |
|---|---|---|---|---|---|
| MD1 | Increase | 3195 | 0.001 | [18, 8, −2], Inferior fronto‐occipital fasciculus R | Anterior thalamic radiation L, Anterior thalamic radiation R, Corticospinal tract L, Corticospinal tract R, Forceps minor, Inferior fronto‐occipital fasciculus L, Inferior fronto‐occipital fasciculus R, Inferior longitudinal fasciculus R, Superior longitudinal fasciculus R, Uncinate fasciculus R, Superior longitudinal fasciculus (temporal part) R |
| MD2 | Decrease | 1498 | <0.001 | [−32, −12, 30], Superior longitudinal fasciculus L, Superior longitudinal fasciculus (temporal part) L | Anterior thalamic radiation L, Anterior thalamic radiation R, Corticospinal tract L, Cingulum (cingulate gyrus) L, Inferior fronto‐occipital fasciculus L, Inferior longitudinal fasciculus L, Superior longitudinal fasciculus L, Superior longitudinal fasciculus (temporal part) L |
| MD3 | Decrease | 139 | 0.011 | [−32, 36, 2], Inferior fronto‐occipital fasciculus L, Uncinate fasciculus L, Anterior thalamic radiation L | Anterior thalamic radiation L, Cingulum (cingulate gyrus) L, Forceps minor, Inferior fronto‐occipital fasciculus L, Uncinate fasciculus L, Superior longitudinal fasciculus (temporal part) L |
| RD1 | Increase | 383 | 0.004 | [8, −34, −30], Anterior thalamic radiation R, Corticospinal tract R | Anterior thalamic radiation L, Anterior thalamic radiation R, Corticospinal tract L, Corticospinal tract R |
| RD2 | Increase | 344 | 0.002 | [16, 8, −2], Anterior thalamic radiation R | Anterior thalamic radiation R, Corticospinal tract R, Inferior fronto‐occipital fasciculus R, Superior longitudinal fasciculus R, Superior longitudinal fasciculus (temporal part) R |
| RD3 | Increase | 90 | 0.014 | [22, −22, −8], Corticospinal tract R | Anterior thalamic radiation R, Corticospinal tract R |
| RD4 | Decrease | 1097 | <0.001 | [−32, −10, 30], Superior longitudinal fasciculus L, Superior longitudinal fasciculus (temporal part) L | Anterior thalamic radiation L, Corticospinal tract L, Cingulum (cingulate gyrus) L, Inferior fronto‐occipital fasciculus L, Inferior longitudinal fasciculus L, Superior longitudinal fasciculus L, Superior longitudinal fasciculus (temporal part) L |
| RD5 | Decrease | 143 | 0.014 | [−20, 42, −2], Forceps minor, Anterior thalamic radiation L, Inferior fronto‐occipital fasciculus L, Uncinate fasciculus L | Anterior thalamic radiation L, Cingulum (cingulate gyrus) L, Forceps minor, Inferior fronto‐occipital fasciculus L, Uncinate fasciculus L, Superior longitudinal fasciculus (temporal part) L |
| AD1 | Increase | 5740 | <0.001 | [20, 0, −6], Unclassified | Anterior thalamic radiation L, Anterior thalamic radiation R, Corticospinal tract L, Corticospinal tract R, Cingulum (hippocampus) R, Forceps major, Forceps minor, Inferior fronto‐occipital fasciculus L, Inferior fronto‐occipital fasciculus R, Inferior longitudinal fasciculus L, Inferior longitudinal fasciculus R, Superior longitudinal fasciculus R, Uncinate fasciculus R, Superior longitudinal fasciculus (temporal part) R |
| AD2 | Decrease | 724 | <0.001 | [−34, −6, 34], Superior longitudinal fasciculus L, Superior longitudinal fasciculus (temporal part) L | Anterior thalamic radiation L, Anterior thalamic radiation R, Corticospinal tract L, Cingulum (cingulate gyrus) L, Inferior fronto‐occipital fasciculus L, Superior longitudinal fasciculus L, Superior longitudinal fasciculus (temporal part) L |
Abbreviations: AD, axial diffusivity; L, left; Max., maximum; MD, mean diffusivity; MNI, Montreal Neurological Institute; R, right; RD, radial diffusivity.
a
The JHU WM tractography atlas (Hua et al., 2008) was used to identify brain regions at cluster peak coordinates and subcomponents, no significant clusters with ≥50 voxels were found for fractional anisotropy.