Table 2.

Performance of the assays used in the diagnosis of 18 patients with positive results for Cryptococcus and Histoplasma Ag assays.

#	CD4 count	Result of Ag testing					Case definition based on rapid test
		Histoplasma Ag lateral flow assay	Histoplasma Ag enzyme immunoassay (concentration)	Serum CrAg (titer)	Cerebrospinal fluid CrAg (titer)	Culture
1	53	Positive	Positive (>25 ng/ml)	Negative	Negative	Histoplasma capsulatum	Proven histoplasmosisa
2	94	Positive	Positive (>25 ng/ml)	Negative	Negative	Histoplasma capsulatum	Proven histoplasmosis
3	52	Positive	Positive (>25 ng/ml)	Negative	Negative	Histoplasma capsulatum	Proven histoplasmosis
4	42	Positive	Positive (2.6 ng/ml)	Negative	Negative	Histoplasma capsulatum	Proven histoplasmosis
5	283	Negative	Positive (1.4 ng/ml)	Negative	Negative	Histoplasma capsulatum	Proven histoplasmosis
6	12	Positive	Positive (>25 ng/ml)	Negative	Negative	Histoplasma capsulatum	Proven histoplasmosis / tuberculosisb
7	156	Negative	Positive (2.7 ng/ml)	Negative	Negative	Negative	Probable histoplasmosis
8	54	Positive	Positive (5.3 ng/ml)	Negative	Negative	Negative	Probable histoplasmosis
9	30	Positive	Positive (12.0 ng/ml)	Negative	Negative	Negative	Probable histoplasmosis
10	46	Positive	Positive (1.5 ng/ml)	Negative	Negative	Negative	Probable histoplasmosis
11	194	Positive	Negative	Negative	Negative	Negative	Probable histoplasmosis
12	39	Positive	Negative	Negative	Negative	Negative	Probable histoplasmosis
13	53	Negative	Negative	P (>1:2560)	P (>1:2560)	Cryptococcus neoformans	Cryptococcal meningitis
14	36	Negative	Negative	P (>1:2560)	P (1:80)	Cryptococcus neoformans	Cryptococcal meningitis
15	8	Negative	Negative	P (>1:2560)	P (1:20)	Cryptococcus neoformans	Cryptococcal meningitis
16	41	Negative	Negative	P (1:320)	P (>1:2560)	Cryptococcus neoformans	Cryptococcal meningitis

Ag, antigen; CrAg, Cryptococcus Ag.

^aAcid-fast bacilli in urine smear.

^bDied during the 30-day follow-up.