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. 2024 Jul 29;75:103293. doi: 10.1016/j.redox.2024.103293

Fig. 3.

Fig. 3

CREG1 knockdown aggravated the cardiomyocytes ferroptosis induced by DOX

A-B. Effects of CREG1 knockdown on the expressions of ferroptosis-related proteins in NMCMs with DOX treatment (n = 3). C. The mRNA of Creg1, Ptgs2 and Gpx4 in CREG1-knockdown NMCMs with DOX treatment (n = 3). D-E. Effects of CREG1 knockdown on mitochondrial oxidation in NMCMs using MitoSOX staining (n = 5). F-G. Effects of CREG1 knockdown on mitochondrial membrane potential in NMCMs using JC-1 staining (n = 3). DOX: doxorubicin, NMCMs: neonatal mouse cardiomyocytes. *p < 0.05, **p < 0.01 vs. si-control group; #p < 0.05, ##p < 0.01 vs. si-Creg1 group; &p < 0.05, &&p < 0.01 vs. si-control+DOX group.