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ADC conjugated to payload (MMAE) through peptide (valine-citrulline) linker: Amide bond between valine-citrulline linker and p-amino benzyl alcohol (PABC) is cleaved by lysosomal enzyme and resultant moiety undergoes spontaneous self-immolation of the PABC portion through 1,6-elimination process to release the free payload, MMAE into the tumor cell
