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Various conjugation techniques and reactions for the design of ADCs
| Stochastic (Non-specific) Conjugation Techniques | Site Specific Engineered Conjugation Techniques |
|---|---|
|
| |
| • Lysine amide conjugation: amine reaction • Cysteine conjugation: thiol reaction |
• Engineered cysteine residue (THIOMAB): thiol reactions • Enzymatic conjugation • Glycan conjugation • Engineered unnatural amino acids (UAA): compatible UAA side chain reactions • C-/N-terminal selective conjugation |
