Table 1. Final Population PK Model^a.

parameter		estimate	RSE [%]	BSV [%]	shrinkage [%]
tablet	tlag [h]	0.157	6.00	77.86	21.26
	ka [1/h]	5.08	6.96	107.0	16.05
capsule	tlag [h]	0.36	3.60	28.88	16.89
	ka [1/h]	4.88	6.58	117.34	13.62
CL/F [L/h/70 kg]		75.23	0.85	37.61	0.91
βCL/F, weight		1.21	18.8	-	-
V1/F [L/70 kg]		86.69	1.13	40.69	8.81
βV1/F, weight		0.73	28.2	-	-
Q/F [L/h/70 kg]		41.43	2.61	-	-
V2/F [L/70 kg]		31.38	1.91	25.75	36.31
additive error		0.70	-	-	-
proportional error		0.12	-	-	-

^aβ_CL/F, β_V1/F—scaling exponents for the apparent systemic clearance and apparent volume of the central compartment, respectively; BSV—between-subject variability; CL/F—apparent systemic clearance; k_a—absorption rate constant; Q/F—apparent intercompartmental clearance; RSE—relative standard error; t_lag—lag time; V₁/F—apparent volume of the central compartment; V₂/F—apparent volume of the peripheral compartment.