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. Author manuscript; available in PMC: 2024 Aug 26.
Published in final edited form as: Sci Transl Med. 2022 Dec 21;14(676):eade0424. doi: 10.1126/scitranslmed.ade0424

Figure 4. Activation phenotypes of memory B cells following pre-F or post-F vaccination parallels F probe-binding profiles.

Figure 4.

Representative pre- and post-F probe-binding profiles are shown for a single participant vaccinated with DS-Cav1 (pre-F, N = 30) or MEDI7510 (post-F, N = 30) at W0 and W1. CD27+ B cells were delineated based on expression of surface markers CD27 and CD21 as activated (CD21+CD71+, CD21−CD71−, CD21−CD71+) or resting (CD21+CD71−). F probe-binding B cells were overlaid for each compartment. IgG+ (A) representative activation profiles and (B) activation phenotype by F probe-binding specificity are shown. IgA+ (C) representative activation profiles and (D) activation phenotype by F probe-binding specificity are shown.