Table.
Synergy Scores Based on SynergyFinder
| Drug A | Drug B | ZIP | Loewe | H SA | Bliss |
|---|---|---|---|---|---|
| 92.1 (EIF1AXmut) | |||||
| E7107 | Quisinostat | −5.03 | −0.41 | 2.89 | −5.43 |
| E7107 | Ricolinostat | −7.42 | −1.29 | 2.68 | −7.45 |
| Ricolinostat | Quisinostat | 21.96 | −3.23 | 7.09 | 24.01 |
| Withaferin A | E7107 | 2.03 | 3.01 | 7.91 | 1.97 |
| Withaferin A | Quisinostat | 1.47 | −2.33 | 5.25 | 2.21 |
| Withaferin A | Ricolinostat | 6.38 | 3.28 | 12.4 | 6.92 |
| Mel202 (SF3B1mut) | |||||
| E7107 | Quisinostat | −4.71 | 9.02 | 11 | −4.35 |
| E7107 | Ricolinostat | 1.34 | −4.15 | −5.21 | −3.46 |
| Ricolinostat | Quisinostat | −1.6 | −2.43 | 0.4 | −2.5 |
| Withaferin A | E7107 | 13.39 | 11.95 | 15.05 | 16.26 |
| Withaferin A | Quisinostat | −8.33 | 4.05 | 3.12 | −8.97 |
| Withaferin A | Ricolinostat | 4.76 | 17.04 | 18.36 | 4.43 |
| MP46 (BAP1mut) | |||||
| E7107 | Quisinostat | −1.33 | 5.39 | 7.57 | −2.38 |
| E7107 | Ricolinostat | 6.69 | −8.35 | −9 | 3.5 |
| Ricolinostat | Quisinostat | −10.73 | 4.38 | 3.02 | −11.65 |
| Withaferin A | E7107 | −1.52 | −3.85 | 2.67 | −2.4 |
| Withaferin A | Quisinostat | −10 | 2.74 | 0.02 | −8.23 |
| Withaferin A | Ricolinostat | 9.58 | −0.01 | −3.85 | 2.98 |
A total of four tools are used in SynergFinder: ZIP, Loewe, has, and Bliss. For each combination, the score is given and divided among 92.1, Mel202, and MP46. Synergism or antagonism is highlighted in bold.