Table 2.
The associations of diabetes status and its interaction with brain insulin signaling measures with the decline of late-life cognitive function (N=147).
| Predictors | Estimate (SE, p-value) | |||||
|---|---|---|---|---|---|---|
| Global Cognition | Episodic Memory | Working Memory | Semantic Memory | Perceptual Speed | Visuospatial Abilities | |
| Diabetes | ||||||
| Main Effect | -0.098 (0.182,0.592) | -0.144 (0.225,0.522) | -0.046 (0.138,0.741) | -0.017 (0.202,0.932) | -0.173 (0.176,0.327) | -0.050 (0.136,0.715) |
| Interaction with Time | -0.002 (0.021,0.924) | -0.003 (0.023,0.888) | -0.006 (0.014,0.674) | 0.007 (0.022,0.744) | -0.018 (0.017,0.305) | -0.009 (0.011,0.417) |
| pS307IRS1/total IRS1*Diabetes | ||||||
| Main Effect | -0.005 (0.178,0.979) | -0.076 (0.219,0.731) | -0.009 (0.136,0.950) | 0.040 (0.196,0.838) | 0.038 (0.168,0.820) | 0.062 (0.135,0.646) |
| Interaction with Time | -0.002 (0.021,0.940) | -0.014 (0.023,0.534) | 0.011 (0.014,0.442) | -0.002 (0.022,0.932) | 0.003 (0.017,0.853) | 0.009 (0.012,0.465) |
| pT308AKT1/total AKT1*Diabetes | ||||||
| Main Effect | -0.206 (0.177,0.246) | -0.330 (0.215,0.127) | -0.106 (0.134,0.433) | -0.176 (0.200,0.382) | 0.011 (0.175,0.952) | -0.034 (0.134,0.801) |
| Interaction with Time | -0.015 (0.021,0.473) | -0.030 (0.023,0.192) | 0.005 (0.015,0.718) | -0.013 (0.022,0.558) | -0.005 (0.017,0.777) | -0.011 (0.011,0.327) |
| pS616IRS1 cells/mm2*Diabetes | ||||||
| Main Effect | -0.252 (0.175,0.153) | -0.343 (0.213,0.110) | -0.075 (0.137,0.585) | -0.395 (0.193,0.043) | 0.070 (0.171,0.683) | -0.166 (0.133,0.216) |
| Interaction with Time | -0.026 (0.022,0.240) | -0.024 (0.024,0.323) | -0.026 (0.017,0.117) | -0.046 (0.023,0.051) | 0.014 (0.019,0.471) | 0.008 (0.014,0.593) |
Note: All linear mixed-effects regression models were adjusted for age at death, sex, education, and their interaction with time. Data were from 147 participants with at least two longitudinal observations of cognition. Bold values denote statistical significance (p<0.05).