Table 4.
Associations between brain insulin signaling measures and the decline of late-life cognitive function after adjusting for APOEε4 allele (N=116).
| Predictors | Estimate (SE, p-value) | |||||
|---|---|---|---|---|---|---|
| Global Cognition | Episodic Memory | Working Memory | Semantic Memory | Perceptual Speed | Visuospatial Abilities | |
| ELISA | ||||||
| pS307IRS1/total IRS1 | ||||||
| Main Effect | -0.071 (0.121,0.560) | -0.149 (0.150,0.322) | -0.110 (0.093,0.238) | 0.060 (0.142,0.671) | 0.069 (0.122,0.573) | 0.021 (0.096,0.827) |
| Interaction with Time | -0.002 (0.013,0.875) | -0.002 (0.015,0.916) | -0.001 (0.009,0.891) | 0.005 (0.015,0.772) | 0.001 (0.013,0.917) | -0.002 (0.008,0.800) |
| pT308AKT1/total AKT1 | ||||||
| Main Effect | -0.228 (0.092,0.015) | -0.320 (0.113,0.006) | -0.204 (0.070,0.004) | -0.102 (0.111,0.357) | -0.133 (0.094,0.158) | -0.122 (0.073,0.099) |
| Interaction with Time | -0.017 (0.010,0.092) | -0.020 (0.012,0.093) | -0.017 (0.007,0.022) | -0.003 (0.012,0.802) | -0.011 (0.010,0.274) | -0.014 (0.006,0.024) |
| Immunohistochemistry | ||||||
| pS616IRS1 cells/mm2 | ||||||
| Main Effect | -0.105 (0.080,0.242) | -0.108 (0.111,0.335) | -0.055 (0.070,0.429) | -0.157 (0.105,0.137) | -0.073 (0.090,0.419) | -0.115 (0.071,0.106) |
| Interaction with Time | 0.001 (0.010,0.908) | -0.003 (0.012,0.810) | 0.004 (0.008,0.599) | -0.003 (0.012,0.796) | 0.007 (0.010,0.481) | -0.001 (0.007,0.914) |
Note: All linear mixed-effects regression models were adjusted for age at death, sex, education, APOEε4, and their interaction with time. Data were from 116 participants with at least two longitudinal observations of cognitive function and available information on APOEε4 status. Bold values denote statistical significance (p<0.05).