. 2024 Aug 21;481(16):1075–1096. doi: 10.1042/BCJ20240110

Table 1. In vitro activity (IC₅₀ and K_i values) of DXR inhibitors against TgDXR enzyme.

Compound	IC₅₀ ± S.D. (µM)	K_i (µM)
1	1.03 ± 0.21	0.31^a
2	1.23 ± 0.12	0.37
3	0.64 ± 0.38	0.19
4	0.62 ± 0.12	0.19
5	2.45 ± 0.54	0.74
6	3.90 ± 1.06	1.18
7	5.82 ± 1.52	2.69
8	52.14 ± 0.34	11.00
9	2.44 ± 0.43	0.74
10	7.68 ± 0.87	2.51

The K_i value reported in previous studies is 0.09 µM [37]. Values shown in the table represent the means of three independent experiments each done in duplicate (n = 6) ± S.D.

Table 1. In vitro activity (IC50 and Ki values) of DXR inhibitors against TgDXR enzyme.

Table 1. In vitro activity (IC₅₀ and K_i values) of DXR inhibitors against TgDXR enzyme.