Table 3.
In the METABRIC, TCGA Cohort, a Multivariate Cox Proportional Hazards Regression Analysis Was Conducted to Determine Predictors of Overall Survival (OS) in Breast Cancer
| Characteristics | Multivariate Analysis in METABRIC | Multivariate Analysis in TCGA | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p-value | Hazard Ratio (95% CI) | p-value | |
| ACOT8 | ||||
| Low | Reference | Reference | ||
| High | 1.174 (1.007–1.368) | 0.040 | 1.864 (1.165–2.982) | 0.009 |
| Tumor size | ||||
| ≤ 2.0 cm | Reference | Reference | ||
| > 2.0 cm | 1.779 (1.514–2.090) | < 0.001 | 0.887 (0.509–1.546) | 0.672 |
| Pathologic stage | ||||
| Stage I & Stage II | Reference | Reference | ||
| Stage III & Stage IV | 1.127 (0.951–1.334) | 0.168 | 2.977 (1.802–4.916) | < 0.001 |
| PAM50 | ||||
| TNBC | Reference | Reference | ||
| NTNBC | 0.764 (0.553–1.057) | 0.104 | 0.404 (0.051–3.213) | 0.391 |
| PR status | ||||
| Negative | Reference | Reference | ||
| Positive | 0.813 (0.680–0.972) | 0.023 | 0.866 (0.408–1.841) | 0.709 |
| ER status | ||||
| Negative | Reference | Reference | ||
| Positive | 0.801 (0.601–1.607) | 0.130 | 0.459 (0.181–1.166) | 0.102 |
| HER2 status | ||||
| Negative | Reference | Reference | ||
| Positive | 1.218 (0.946–1.568) | 0.127 | 1.233 (0.658–2.311) | 0.514 |