Table 2.

Leading SNPs from GWAS of cortical clock: meta-analysis of ROSMAP and BDR.

	Chr:pos	Effect allele	Non-effect	EAF	beta	p-value	Gene annotation
Rs4844620	1:207980901	A	G	0.12	0.886	1.29E-07	CD46	Membrane cofactor 9, protects injury by complement, modulates T cell activation. inflammatory disorders, cancers
rs17187636	2:166309615	A	G	0.08	1.266	1.17E-06	CSRNP3, GALNT3, FIGN	CSRNP3: DNA-binding transcription factor, apoptotic processes and transcriptional activity, related to education, bone density GALNT3: oligosaccharide biosynthesis, phosphate homeostasis FIGN: microtubule organization, locomotion, neuropathy
rs17743504	17:10080837	A	T	0.12	1.008	1.47E-06	GAS7	In purkinje neurons, intraocular pressure, glaucoma
Rs34403329	8:18029698	A	G	0.35	−0.826	2.48E-06	NAT1	Folate catabolism, bladder cancer, urate, depression, blood pressure
Rs13180000	5:50132506	A	T	0.22	−0.825	1.66E-06	PARP8	Protein ADP-ribosylase activity, diabetes, complement component C6
rs9557340	13:100580750	A	G	0.32	0.713	2.97E-06	CLYBL	Mitochondrial enzyme, regulation of cobalamin metabolic process, vitamin B12 levels
rs2593685	11:22391419	T	C	0.41	0.671	3.65E-06	SLC17A6	Neurotransmitter transporter, synaptic activity
rs4979892	10:79341734	T	C	0.46	−0.626	6.39E-06	KCNMA1 DLG5	KCNMA1: potassium channel, smooth muscle contraction, neurotransmitter release, neuron excitability, epilepsy DLG5: cell scaffolding, cell proliferation, dendritic spine formation, synaptogenesis
rs4253425	4:187205929	A	C	0.10	0.959	6.56E-06	F11 CYP4V2 KLKB1	F11: coagulation factor XI, clotting, VTE, TPA levels
rs836815	5:79995116	A	G	0.30	−0.679	7.52E-06	MSH3	DNA repair, cortical thickness, huntington disease, endometrial cancer
rs13105396	4:17047358	T	C	0.06	1.445	7.79E-06	CPB2	Hydrolyze c-terminal peptide bonds, downregulates fibrinolysis, complement cascade, thrombosis
rs79932664	21:43779709	T	C	0.09	1.038	7.87E-06	TFF1	Secretory protein
rs17111206	1:94646439	A	G	0.06	1.321	9.39E-06	ARHGAP29	Rho GTPase signaling, cleft palate